This assay quantifies a selected protein within the blood answerable for transporting glucocorticoid hormones, equivalent to cortisol. This protein performs an important function in regulating the bioavailability of those hormones, influencing their exercise in varied tissues. For instance, low ranges of this protein may end up in larger ranges of free, unbound cortisol, probably resulting in scientific manifestations of hypercortisolism even when whole cortisol ranges seem regular. Conversely, elevated ranges can lower free cortisol, mimicking hypocortisolism.
Measurement of this protein is clinically important as a result of it aids within the correct evaluation of glucocorticoid standing. Its ranges are affected by a wide range of circumstances, together with being pregnant, liver illness, thyroid problems, and genetic elements. Understanding its focus contributes to the right prognosis and administration of endocrine problems, notably these associated to adrenal operate. Traditionally, evaluation of adrenal operate relied closely on whole cortisol measurements; nevertheless, recognizing the affect of this binding protein has refined diagnostic approaches.
